Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
Identifieur interne : 000073 ( Main/Exploration ); précédent : 000072; suivant : 000074Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
Auteurs : K. Brockmann [Allemagne] ; C. Schulte [Allemagne] ; N. Schneiderhan-Marra [Allemagne] ; A. Apel [Allemagne] ; C. Pont-Sunyer [Espagne] ; D. Vilas [Espagne] ; J. Ruiz-Martinez [Espagne] ; M. Langkamp [Allemagne] ; J-C Corvol [France] ; F. Cormier [France] ; T. Knorpp [Allemagne] ; T O Joos [Allemagne] ; A. Bernard [Allemagne] ; T. Gasser [Allemagne] ; C. Marras [Canada] ; B. Schüle [États-Unis] ; J O Aasly [Norvège] ; T. Foroud [États-Unis] ; J F Marti-Masso [Espagne] ; A. Brice [France] ; E. Tolosa [Espagne] ; D. Berg [Allemagne] ; W. Maetzler [Allemagne]Source :
- European journal of neurology [ 1468-1331 ] ; 2017.
Abstract
The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.
DOI: 10.1111/ene.13223
PubMed: 28102045
Affiliations:
- Allemagne, Canada, Espagne, France, Norvège, États-Unis
- Bade-Wurtemberg, Californie, Catalogne, District de Tübingen, Indiana, Ontario, Trøndelag, Île-de-France
- Barcelone, Paris, Toronto, Trondheim, Tübingen
- Université de Barcelone, Université de Toronto
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Le document en format XML
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<wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Ruiz Martinez, J" sort="Ruiz Martinez, J" uniqKey="Ruiz Martinez J" first="J" last="Ruiz-Martinez">J. Ruiz-Martinez</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea>
<wicri:noRegion>Guipuzcoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Langkamp, M" sort="Langkamp, M" uniqKey="Langkamp M" first="M" last="Langkamp">M. Langkamp</name>
<affiliation wicri:level="1"><nlm:affiliation>Mediagnost GmbH, Reutlingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mediagnost GmbH, Reutlingen</wicri:regionArea>
<wicri:noRegion>Reutlingen</wicri:noRegion>
<wicri:noRegion>Reutlingen</wicri:noRegion>
<wicri:noRegion>Reutlingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Corvol, J C" sort="Corvol, J C" uniqKey="Corvol J" first="J-C" last="Corvol">J-C Corvol</name>
<affiliation wicri:level="3"><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cormier, F" sort="Cormier, F" uniqKey="Cormier F" first="F" last="Cormier">F. Cormier</name>
<affiliation wicri:level="3"><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knorpp, T" sort="Knorpp, T" uniqKey="Knorpp T" first="T" last="Knorpp">T. Knorpp</name>
<affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea>
<wicri:noRegion>Reutlingen</wicri:noRegion>
<wicri:noRegion>Reutlingen</wicri:noRegion>
<wicri:noRegion>Reutlingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Joos, T O" sort="Joos, T O" uniqKey="Joos T" first="T O" last="Joos">T O Joos</name>
<affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea>
<wicri:noRegion>Reutlingen</wicri:noRegion>
<wicri:noRegion>Reutlingen</wicri:noRegion>
<wicri:noRegion>Reutlingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bernard, A" sort="Bernard, A" uniqKey="Bernard A" first="A" last="Bernard">A. Bernard</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marras, C" sort="Marras, C" uniqKey="Marras C" first="C" last="Marras">C. Marras</name>
<affiliation wicri:level="4"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schule, B" sort="Schule, B" uniqKey="Schule B" first="B" last="Schüle">B. Schüle</name>
<affiliation wicri:level="2"><nlm:affiliation>Parkinson Institute and Clinical Center, Sunnyvale, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Parkinson Institute and Clinical Center, Sunnyvale, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J O" last="Aasly">J O Aasly</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, St Olavs Hospital, Trondheim, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Neurology, St Olavs Hospital, Trondheim</wicri:regionArea>
<placeName><settlement type="city">Trondheim</settlement>
<region type="région" nuts="2">Trøndelag</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foroud, T" sort="Foroud, T" uniqKey="Foroud T" first="T" last="Foroud">T. Foroud</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marti Masso, J F" sort="Marti Masso, J F" uniqKey="Marti Masso J" first="J F" last="Marti-Masso">J F Marti-Masso</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea>
<wicri:noRegion>Guipuzcoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name>
<affiliation wicri:level="3"><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name>
<affiliation wicri:level="4"><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Berg, D" sort="Berg, D" uniqKey="Berg D" first="D" last="Berg">D. Berg</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maetzler, W" sort="Maetzler, W" uniqKey="Maetzler W" first="W" last="Maetzler">W. Maetzler</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">European journal of neurology</title>
<idno type="eISSN">1468-1331</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Norvège</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Californie</li>
<li>Catalogne</li>
<li>District de Tübingen</li>
<li>Indiana</li>
<li>Ontario</li>
<li>Trøndelag</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Paris</li>
<li>Toronto</li>
<li>Trondheim</li>
<li>Tübingen</li>
</settlement>
<orgName><li>Université de Barcelone</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Brockmann, K" sort="Brockmann, K" uniqKey="Brockmann K" first="K" last="Brockmann">K. Brockmann</name>
</region>
<name sortKey="Apel, A" sort="Apel, A" uniqKey="Apel A" first="A" last="Apel">A. Apel</name>
<name sortKey="Berg, D" sort="Berg, D" uniqKey="Berg D" first="D" last="Berg">D. Berg</name>
<name sortKey="Bernard, A" sort="Bernard, A" uniqKey="Bernard A" first="A" last="Bernard">A. Bernard</name>
<name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name>
<name sortKey="Joos, T O" sort="Joos, T O" uniqKey="Joos T" first="T O" last="Joos">T O Joos</name>
<name sortKey="Knorpp, T" sort="Knorpp, T" uniqKey="Knorpp T" first="T" last="Knorpp">T. Knorpp</name>
<name sortKey="Langkamp, M" sort="Langkamp, M" uniqKey="Langkamp M" first="M" last="Langkamp">M. Langkamp</name>
<name sortKey="Maetzler, W" sort="Maetzler, W" uniqKey="Maetzler W" first="W" last="Maetzler">W. Maetzler</name>
<name sortKey="Schneiderhan Marra, N" sort="Schneiderhan Marra, N" uniqKey="Schneiderhan Marra N" first="N" last="Schneiderhan-Marra">N. Schneiderhan-Marra</name>
<name sortKey="Schulte, C" sort="Schulte, C" uniqKey="Schulte C" first="C" last="Schulte">C. Schulte</name>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Pont Sunyer, C" sort="Pont Sunyer, C" uniqKey="Pont Sunyer C" first="C" last="Pont-Sunyer">C. Pont-Sunyer</name>
</region>
<name sortKey="Marti Masso, J F" sort="Marti Masso, J F" uniqKey="Marti Masso J" first="J F" last="Marti-Masso">J F Marti-Masso</name>
<name sortKey="Ruiz Martinez, J" sort="Ruiz Martinez, J" uniqKey="Ruiz Martinez J" first="J" last="Ruiz-Martinez">J. Ruiz-Martinez</name>
<name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name>
<name sortKey="Vilas, D" sort="Vilas, D" uniqKey="Vilas D" first="D" last="Vilas">D. Vilas</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Corvol, J C" sort="Corvol, J C" uniqKey="Corvol J" first="J-C" last="Corvol">J-C Corvol</name>
</region>
<name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name>
<name sortKey="Cormier, F" sort="Cormier, F" uniqKey="Cormier F" first="F" last="Cormier">F. Cormier</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Marras, C" sort="Marras, C" uniqKey="Marras C" first="C" last="Marras">C. Marras</name>
</region>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Schule, B" sort="Schule, B" uniqKey="Schule B" first="B" last="Schüle">B. Schüle</name>
</region>
<name sortKey="Foroud, T" sort="Foroud, T" uniqKey="Foroud T" first="T" last="Foroud">T. Foroud</name>
</country>
<country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J O" last="Aasly">J O Aasly</name>
</region>
</country>
</tree>
</affiliations>
</record>
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